Architecture: Windows Server 2012 R2, latest updates applied, Windows 10 Pro laptops (Lenovo), with folder redirection/ offline files.
Description of problem: When disabling offline files on an end-users machine, once rebooted the machine can see the locally saved profile (C:\Users\%username%\OneDrive), and all the files on OneDrive in there. The OneDrive service starts and appears to be working fine, no errors. However, when opening Office files, they either open but don't display anything or will throw an error essentially saying the resource is not there, check file path etc. This also happens on synced SharePoint Online folders in File Explorer.
We only have Documents and Desktop set to redirect. Which don't appear in the C:\Users\%username%\ folder as they follow the UNC path \DOMAIN\Redirected\Desktop.
I've tested this on 2 machines, and have no reason to believe it would be different on others.
I can confirm the profiles tested on were both local profile, we don't have roaming profiles set-up (I don't think), however when connected to the domain, you can sign into any domain connected machine (I'm not a wiz with Windows Server, but trying to learn).
My expectation is that OneDrive should work regardless of offline files being disabled or enabled. Or is that wrong?
I should also note, disabling offline files then connecting to the server via VPN resolves the issue with OneDrive, files on OD & SPO (in file explorer) will open fine again.
Any advice on the issue or pointing me in the direction of more info would be greatly appreciated.