Hi @Ohshima Yousuke ,
WebView2 uses the Microsoft Edge (Chromium) as the rendering engine to display the web content in native apps, and Microsoft Edge Chromium is supported on Windows 10 Enterprise 2016 LTSC (previously LTSB) so yes it should work.
WebView 2 - Supported platforms
https://learn.microsoft.com/en-us/microsoft-edge/webview2/#supported-platforms
Microsoft Edge supported Operating Systems
https://learn.microsoft.com/en-us/deployedge/microsoft-edge-supported-operating-systems
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Best regards,
Leon