Hello,
Thanks for reaching out.
I believe it could be issue with the Application itself.
I would suggest you to un public app then reboot RDS server if its possible. Then publish the App again.
Also, suggest you to check with other published app like Notepad.exe or Calc.exe if these app crashes or not with different users logged in.
Other note Please check in your Antivirus program if this App and its installation location is whitelisted.
Hope this helps in your case.
Thank you.