Hi AngelArcoraci-1053,
Welcome to our Microsoft Q&A platform!
You can try to the following steps to handle it.
1.Go to info.plist and modify the Minimum system version
2.Check the Apple SDK Location in Preferences
3.Open the Xcode and launch a simulator
4.Restart the VS for Mac
Since the VS and Xamarin.iOS for Xcode13 is not released yet, please submit an issue on GitHub: xamarin/xamarin-macios/Milestones/Xcode13 if the upon steps not work.
Regards,
Kyle
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