Hello,
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Xamarin.iOS latest version supports for Xcode 12.5 and iOS 14. If you use VS 2019 16.11.3 and Xcode12.5, you could have a try to use Manuan Provisioning
and check the profile in your mac . However, it doesn't include the iOS 15 SDKs APIs, if you use new features, some unknown error may occur when you deploy it to device.
For more nformation, you can refer to
https://learn.microsoft.com/en-us/xamarin/ios/deploy-test/provisioning/
https://github.com/xamarin/xamarin-macios/issues/12778
Best Regards,
Wenyan Zhang
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