Hi @bala198222 ,
No, DPM 2012/2012 R2 cannot be installed on Windows Server 2019, and it cannot either back up Windows Server 2019.
For more information, you may refer to the official Microsoft documentation below:
System Center 2012 Agent Requirements for System Center 2012 R2
https://learn.microsoft.com/en-us/previous-versions/system-center/system-center-2012-r2/dn281931(v=sc.12)
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Leon