Hi @EXTERNAL Kotapati Vikram (Klaus It, MS/EOS1-BE1) ,
I think Web App is the best choice. Bellow is a tutorial on how to setup a python app in Azure:
https://learn.microsoft.com/en-us/azure/app-service/quickstart-python?tabs=bash&pivots=python-framework-flask
The WebApp PaaS solution will manage the software stack for you plus a lot of other options (auto-scaling, custom-domains, certificates, deployment).
Hope this helps!