There is one thing to keep in mind that won't work properly if you are still using older agents and that is agent initiated maintenance mode. SCOM 2016 uses for this a solution using a registry key and SCOM 2019 does it with events. So if you initiate maintenance mode from a SCOM 2016 agent using Start-SCOMAgentMaintenanceMode
This goes a bit in detail how to use that CMDlet, however it is a bit outdated : https://social.technet.microsoft.com/wiki/contents/articles/51574.scom-enabling-maintenance-mode-from-agent-computer.aspx
If you are not using this feature then this is at least one thing less to worry about.