Hi,
If you created multiple targeting items to a preference item ,you can combine the the logical operation OR AND to target the users or computers.
As said in the article ,If you have Each targeting item results in a value of either true or false. You can apply multiple targeting items to a preference item and select the logical operation (AND or OR) by which to combine each targeting item with the preceding one.
If the combined value of all targeting items for a preference item is false, then the settings in the preference item are not applied to the user or computer.
Or you can tell us what result do you want ,i can do a test in my lab.
Best Regards,