I have a user that has Office 2019 (retail, not 365). Her outlook profile keeps getting corrupted. I have created new profiles numerous times, and it only works for a day. The next time the machine boots up, she gets the error "Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened. The operation failed". Earlier this week I went as far as creating a new user account. No joy, still doing the same thing. She has three 365 mailboxes configured. A different user on the same machine has the same setup (3 mailboxes), and his account works flawlessly. Not sure where to go with this; if it was a 365 app, I could get MS support directly, but it's not, so I can't.