We have a terminal server running on 2012 R2 with Office 2016. My users (5) have been able to open files from SharePoint Online all the way up to Monday this week. Now when they go to open an office file from SharePoint it gives a generic error message like it doesn't know the format or it can't be found in both Excel and Word. It is not a permission issue as the user is logged in to Office 2016 and SharePoint online with the same creds and the user can open in the SharePoint online view.
It does seem have happened around the recent May updates but it didn't start for 4 days after.
On the same network I have a workstation with Win 10 and Office 2016 that is not having a problem.
I've tried with no luck the below
Running a repair on Office 2016
Removing OneDrive for Business that was installed with Office 2016 (this caused the issue to go away until reboot)
Clearing the cache in the Upload center of all users on the terminal server via deleting the files in the OfficeFileName folder and rebooting
I tried to remove the updates that seemed to be with the whole office suite KB5001923 KB5001920
I've contacted Office 365 support as this issue is only happening with SharePoint online files but they do not seem to keen to help so any other ideas would be greatly appreciated
Thanks
Sean