Hi,
"Renamed and Removed the index folder ending with .single"
-Which .singel folder do you mean? In the mailbox database folder, there will be a sub-folder with a GUID for the name, which contains the content index files. Delete that GUID folder: https://practical365.com/exchange-2016-failed-content-index/
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Check Event log, if you see EventID 1012, follow this blog to fix: https://social.technet.microsoft.com/wiki/contents/articles/31215.exchange-2013-fast-search-technology-failed.aspx
You can also try moving a user to another database, see if it works after that.
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