The environment here consists of a Windows Server 2012 R2 as the domain controller and about forty workstation all running Windows 10. On only a hand full of workstations, we occasionally (about once a month) experience an issue where all the user profiles get deleted. When the user signs in, it creates a brand new profile. All the previous profiles are completely gone with no trace. There is not a Windows.000 or any other copies. The registry profilelist doesn't show any other profiles either. I do keep my workstations backed up so I've been able to restore them, but it's still too much productivity loss for the user. How do I prevent this from happening? I've found lots of discussions about corrupted profiles, but it does not appear that is the case here.