Hi @OHPRS Admin
Is your environment a cloud only one or a hybrid? Did you have on-prem exchange server before? And how do you configure the autodiscover for your environment now?
According to my reasearch, this issue may be caused by outlook found your autodiscover SRV record that is configured for the email domain, if you have configured the SRV record previously, you could remove the record. You could refer to this: How To Check Exchange Autodiscover SRV Record Using Nslookup
Details: How to: Fix Microsoft Outlook keep asking autodiscover.xml (Allow this website to configure email server settings?)
Please Note: Since the web site is not hosted by Microsoft, the link may change without notice. Microsoft does not guarantee the accuracy of this information.
Issue: After migrated/moved to O365, from on-premises exchange server, Outlook on the same network with domain controller/DNS server keeps asking permission for autodiscover.
Fix: Remove the SRV record
And if this is not your case, try clearing the related cached information in credential manager control panel then create a new outlook profile for your user.
In addition, have you tried selecting the option Don't ask me about this website again to see if any help?
The official document here provided a method by set a registry value: How to suppress the AutoDiscover redirect warning in Outlook
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