Vista Keyboard Shortcuts

Killer list of Vista keyboard shortcuts here.

My favorite - launch any application by hitting the WinKey and then start typing the name (e.g. Word) hit enter and it launches.  This is absolutely awesome. 

I can't stand trying to find an application by navigating through the Start Programs menu.  Now I never have to do it again! 

I used to use a tool called Launchy to do this in Windows XP.   If you're still on XP I highly recommend checking it out!