Spam is killing me

My personal e-mail account has just gotten hammered with spam. Not sure what to do anymore. I get about 30 messages a day that don't get filtered away, and I simply can't be bothered to figure out what is going on. I've been toying with the idea of using mailblocks or just switching to using hotmail for all my non-work e-mail.

Challenge/Response seems pretty compelling at this point since I'd rather shift the burden to people trying to send me mail. I get like 5 messages a week sent to my personal e-mail account, so there isn't much value add for me to deal with the spam.