Hi,
Make sure whether it is an update or upgrade on your system.
If it is a update package such as (KB###) which will keep your existing system version, we could uninstall it through Control Panel\Programs and features\view installed update.
If it is a feature update which will upgrade system to an upper system version, such as Windows 10 1909 to Windows 10 2004, we could roll back to previous system version through Settings\Update&Security\Recovery\Go back to previous system version.
But I would recommend to update graphic driver and BIOS driver to latest version from device manufacturer website and check if fallout 4 have latest version for your system before uninstall update or roll back.
Bests,
Joy.