I also have this issue.
I have a multi-monitor setup with three 4k monitors.
Windows 10
32GB RAM
5600x AMD processor
nVidia 3080 Ti graphics card
It most often occurs with apps installed from the windows store. When I click into certain apps the entire screen the app is on will go black. My other monitors will generally stay on, but occasionally multiple will go black too.
When I click out of the app, even if the app still displays on that screen, after ~10s the screen will come back on.
When I take screenshots while the screen is black, everything appears normal.
When I remote stream with something like nVidia Game stream, everything works normally on the stream, even if the actual screen itself is black.
Example apps this happens with
Windows Remote Desktop (both with RemoteDesktop_1.2.4582.0_x64.msi version and windows store version) - it always happens with this app
Adguard - sometimes
Deepl (windows store app) - sometimes
This never happens with web browsers such as chrome, firefox, edge
This sometimes happens when playing video games
Usually a reboot solves the issues with apps that sometimes cause the screen to go black, but e.g. for Windows Remote Desktop the app is basically unusable for me as my screen goes black every time I click into it, and it's terrible if I go fullscreen across 3 monitors
This issue has been occuring for me for a few years, but I can generally avoid running into it by using installer apps rather than windows store apps
I've reinstalled windows twice during that time, once with a repair and once with a completely fresh install and disk wipe.