@David McBride Thanks for posting in our Q&A.
AppLocker is a feature in Windows Security and it is not a built-in feature in intune. Honestly, I'm not familiar with it.
For the Defender technologies to combat crypto type malware, I have done a lof of research. I find an article about Defending against cryptojacking with Microsoft Defender for Endpoint and Intel TDT. Please read it and check if it is what you need:
https://www.microsoft.com/security/blog/2021/04/26/defending-against-cryptojacking-with-microsoft-defender-for-endpoint-and-intel-tdt/
Hope it will help
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