A mail flow rule should do it.
https://learn.microsoft.com/en-us/microsoft-365/compliance/define-mail-flow-rules-to-encrypt-email?view=o365-worldwide
You could have the criteria be the recpient address contains 'com.o' for example
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Hi,
In our hybrid environment we have a send connector configured that sends mails to a third party encryption smart host if a mail address contains .e ending (john.snow@Company portal .com.e).
Can we replicate the same logic for Office Message Encryption service? So mails would be encrypted, if .o ending is in recipients address?
A mail flow rule should do it.
https://learn.microsoft.com/en-us/microsoft-365/compliance/define-mail-flow-rules-to-encrypt-email?view=o365-worldwide
You could have the criteria be the recpient address contains 'com.o' for example
If you want to also use that mail flow rule to also route to a specific send connector as well, you can do that with Conditional Routing.
Note that you have to create a connector that is designed for a mail flow rule and that connector can point to a smarthost.
then once created:
For *Do the following..., choose Redirect the message to... and then specify the following connector. The select connector box appears. Choose the Outbound connector you created previously.
Otherwise, thats the only real way to force OME on messages.