AppDomain is still unloaded when web.config file is changed even File Change Notifications (FCN) are disabled

Let's assume that you are running an ASP.NET application and you disable the File Change Notifications in web.config file (for ASP.NET 4.5 or later) or in the registry as explained inĀ

However the appDomains are still unloaded and reloaded when you change a web.config file.