Clickonce: Clickonce Deployment through Application virtualization
Clickonce Deployment is by design Created to Deploy in Per-user Environment
We could not change the Target path to Clickonce Application. By default Clickonce would only Point to Root Drive\%User Profile%\Local\Apps
-Generally through Soft grid or Citrix server virtual Drive would be created and Deployment would be to those virtual Drive.
-Clickonce would not completely work on those environment as it wouldn't understand the Virtual drive location and still try to Deploy to the Default Local drive of the machine
-Clear the Clickonce cache through Mage -cc or manually Deleting %userprofile%\Apps Folder
-Clickonce on Virtual environment is not the best Practice. Allow click once to Deploy to Local drive and than programmatically try to transfer Content of Clickonce Cache to Virtual Directory