Referring to All the Cells on the Worksheet [Excel 2003 VBA Language Reference]

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When you apply the Cells property to a worksheet without specifying an index number, the method returns a Range object that represents all the cells on the worksheet. The following Sub procedure clears the contents from all the cells on Sheet1 in the active workbook.

Sub ClearSheet()
    Worksheets("Sheet1").Cells.ClearContents
End Sub

See Also | Referring to Cells by Using a Range Object | Referring to Named Ranges