Block syncing of specific file types
You can prevent users from uploading specific file types when they sync their OneDrive files.
You must sign in as a global or SharePoint admin in your organization.
If you're signed in to your browser with a work or school account that isn't an admin, you'll see the Sync page, but the contents won't appear.
If you're signed in to your browser with a Microsoft account, your personal OneDrive will appear.
This setting prevents file types from being uploaded but not downloaded. If users already have blocked file types in their OneDrive, the files will sync to their computer, but any changes they make on their computer won't be uploaded.
To block uploading of specific file types
Open the OneDrive admin center, and click Sync in the left pane.
Select the Block syncing of specific file types check box.
Type the file name extensions you want to block, for example: exe or mp3.
Do not include the periods with the extensions, or any other punctuation, spaces, or special characters.
Click Save on the Sync page.
For info about setting this sync app restriction by using PowerShell, see Set-SPOTenantSyncClientRestriction
When you configure this setting, it takes approximately 8 hours for the OneDrive sync app to detect it and apply the change.